Pleomorphic Liposarcoma
Synonyms: High-grade liposarcoma variant
Highest-grade liposarcoma variant
Quick Facts
Behaviour
Malignant
Category
Soft tissue
Grade
High
Synonyms
High-grade liposarcoma variant
Category
Soft tissue
Behaviour
Malignant
Grade
High
Gender
M = F
Tissue of Origin
Adipose
Epidemiology
- Rare High-grade liposarcoma variant
- Peak incidence in middle-aged adults
- Lower extremity predominance
Clinical Features
- Large, rapidly growing mass
- Often presents with advanced disease
Location
- Lower extremity
- Retroperitoneum
Imaging
- MRI: heterogeneous High-grade appearance
- Minimal lipid content - mostly solid
Pathology
- Pleomorphic lipoblasts and undifferentiated sarcoma
- High mitotic rate, extensive necrosis
- Liposarcoma grade 3 (Highest)
Genetics
- Complex karyotype
- FUS, MDM2 may be present
Treatment
- Wide surgical excision
- Chemotherapy indicated
Prognosis
Poor - High-grade malignancy with metastatic potential
Key Points
- Highest-grade liposarcoma variant
- Aggressive behaviour - multimodal therapy required
Workup - Blood Tests
FBC, U&E, LFTs, LDH - baseline
Workup - Local Imaging
- MRI primary site - local staging
- CT chest/abdomen/pelvis - metastatic staging
Workup - Biopsy
Core needle biopsy - confirm diagnosis
Workup - Staging
CT chest/abdomen/pelvis - metastases
Follow-up Summary
- 1
Year 1
Post-operative at 6 weeks; 3–4 monthly clinical examination and CXR
- 2
Year 2
3–4 monthly clinical examination and CXR
- 3
Years 3–4
6-monthly clinical examination and CXR
- 4
Years 5–10
Annual clinical examination and CXR
- 5
Discharge at 10 years after surgery
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