Granular Cell Tumour
Synonyms: Granular cell myoblastoma, Abrikossoff tumour
Benign Neural tumour
Quick Facts
Behaviour
Benign
Category
Soft tissue
Synonyms
- Granular cell myoblastoma
- Abrikossoff tumour
Category
Soft tissue
Behaviour
Benign
Gender
Female
Tissue of Origin
Neural
Epidemiology
- Benign nerve sheath tumour derivative
- Peak incidence in 3rd-5th decades
- Female predilection particularly in breast
Clinical Features
- Firm subcutaneous nodule
- Often solitary
- Usually painless
- Breast presentation can mimic malignancy
Location
- Skin and subcutaneous (most common)
- Breast
- Respiratory tract
- GI tract
Imaging
- MRI: well-defined lesion
- Ultrasound: hypoechoic nodule
Pathology
- Nested cells with abundant granular cytoplasm
- S100+, neuron-specific enolase+
- No atypia
Genetics
Sporadic
Treatment
- Observation or surgical excision
- Complete excision reduces recurrence
Prognosis
Excellent - Benign, rare transformation to malignancy
Key Points
- Benign Neural tumour
- Rarely undergo Malignant transformation
Workup - Blood Tests
No specific blood tests
Workup - Local Imaging
MRI or ultrasound for characterisation
Workup - Biopsy
Biopsy if diagnosis uncertain
Workup - Staging
No staging required
Workup - Other
Excision for definitive diagnosis and treatment
Follow-up Summary
- 1
Year 1
Post-operative visit within first 6 weeks, then supported discharge
Medical disclaimer
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