Angiomyofibroblastoma
Benign vulvovaginal tumour in reproductive-age women
Quick Facts
Behaviour
Benign
Category
Soft tissue
Category
Soft tissue
Behaviour
Benign
Gender
Female (10:1)
Tissue of Origin
Fibrous
Epidemiology
- Rare benign tumour almost exclusively in women
- Reproductive age most common
- Vulvovaginal region predilection
Clinical Features
- Asymptomatic, slowly progressing, well defined mass
- Often misdiagnosed as a Bartholin cyst
Location
- Vulvovaginal region
- Perineum, scrotum, inguinal regions
Imaging
USS: solid, well demarcated, vascularized lesion, hyperechoic areas with irregular and small hypoechoic cystic areas
Pathology
- Alternating hypercellular and hypocellular areas
- Epithelioid to spindled cells around vessels
Genetics
Sporadic RB1 alterations occasionally reported
Treatment
- Simple marginal excision
- No need for wide margins
Prognosis
- Excellent - recurrence after complete excision is rare
- No malignant potential
Key Points
- Benign vulvovaginal tumour in reproductive-age women
- Must be distinguished from aggressive angiomyxoma (which is infiltrative)
- Simple excision curative
Workup - Blood Tests
No blood tests required
Workup - Local Imaging
MRI with contrast of primary site
Workup - Biopsy
Excision biopsy or core needle biopsy if clinical diagnosis uncertain
Workup - Staging
No staging required
Follow-up Summary
Medical disclaimer
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