Angiofibroma of Soft tissue
Benign lesion located in the soft tissues of the extremities, often in association with joints or fibrotendinous structures
Quick Facts
Behaviour
Benign
Category
Soft tissue
Category
Soft tissue
Behaviour
Benign
Gender
M = F
Tissue of Origin
Vascular
Epidemiology
Wide age range with peak incidence in middle aged adults
Clinical Features
- Slow growing, painless mass
- Well demarcated
Location
- Extremities most common, specifically lower limbs
- Often near large joints
- Can be either subcutaneous or deep
Imaging
MRI: well circumscribed mass, variable signal characteristics and enhancement
Pathology
Myxoid and collagenous stroma with bland spindle cells
Genetics
NCOA2 gene rearrangements
Treatment
- Simple marginal excision
- No need for wide margins
Prognosis
- Excellent - recurrence after complete excision is rare
- No malignant potential
Key Points
Benign lesion located in the soft tissues of the extremities, often in association with joints or fibrotendinous structures
Workup - Blood Tests
No blood tests required
Workup - Local Imaging
MRI with contrast of primary site
Workup - Biopsy
Excision biopsy or core needle biopsy if clinical diagnosis uncertain
Workup - Staging
No staging required
Follow-up Summary
Medical disclaimer
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